منابع مشابه
Pathogen inactivation technologies for cellular blood components: an update.
Nowadays patients receiving blood components are exposed to much less transfusion-transmitted infectious diseases than three decades before when among others HIV was identified as causative agent for the acquired immunodeficiency syndrome and the transmission by blood or coagulation factors became evident. Since that time the implementation of measures for risk prevention and safety precaution ...
متن کاملPathogen Inactivation of Platelet and Plasma Blood Components for Transfusion Using the INTERCEPT Blood SystemTM
Background: The transmission of pathogens via blood transfusion is still a major threat. Expert conferences established the need for a pro-active approach and concluded that the introduction of a pathogen inactivation/reduction technology requires a thorough safety profile, a comprehensive pre-clinical and clinical development and an ongoing hemovigilance program. Material and Methods: The INTE...
متن کاملPathogen Inactivation of Platelet and Plasma Blood Components for Transfusion Using the INTERCEPT Blood System™
BACKGROUND: The transmission of pathogens via blood transfusion is still a major threat. Expert conferences established the need for a pro-active approach and concluded that the introduction of a pathogen inactivation/reduction technology requires a thorough safety profile, a comprehensive pre-clinical and clinical development and an ongoing hemovigilance program. MATERIAL AND METHODS: The INTE...
متن کاملPhenothiazinium derivatives for pathogen inactivation in blood products.
Phenothiazine-based photosensitisers have been employed in photoantimicrobial research for nearly 80 years, both as lead and novel compounds. However, the main structural variations have mainly involved the auxochromic side chains and little has been reported concerning either peripheral substitution or structures with chromophores other than those of the phenothiazinium or annelated benzo[a]ph...
متن کاملPathogen reduction of blood components and plasma derivatives
The pathogen safety of plasma derivative and labile blood components has been dramatically enhanced over the last 25 years through the implementation of nucleic acid testing (NAT) technologies that effectively screen out units with high virus titers. Additionally, the incorporation of pathogen inactivation (PI) and removal steps into the manufacturing processes of plasma-derived medicinal produ...
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ژورنال
عنوان ژورنال: Transfusion Alternatives in Transfusion Medicine
سال: 2008
ISSN: 1295-9022,1778-428X
DOI: 10.1111/j.1778-428x.2008.00113.x